Acid responsiveness of emissive morpholinyl aminoquinolines and their use for cell fluorescence imaging?
Organic & Biomolecular Chemistry Pub Date: 2022-05-06 DOI: 10.1039/D2OB00546H
Abstract
Herein, we report emissive aminoquinoline derivatives (TFMAQ) containing alkylmorpholine and arylmorpholine groups and their photophysical properties, acid-responsiveness, and organelle targeting. The alkylmorpholine group is well-known to favour accumulation in lysosomes and be acid-responsive, but, counterintuitively, the TFMAQ derivatives containing ethylmorpholine groups showed limited accumulation in lysosomes and, instead, preferential accumulation in lipid droplets. The findings reported here will aid the development of organelle/tissue specific dyes for cell imaging and diagnosis.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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