Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched γ-lactams?
Organic & Biomolecular Chemistry Pub Date: 2022-07-21 DOI: 10.1039/D2OB01040B
Abstract
An unprecedented organocatalytic process involving the asymmetric addition of azide to meso-anhydrides has been developed, promoted by novel sulfamide-substituted Cinchona alkaloid-based catalysts. Readily available glutaric anhydrides can be smoothly converted to enantioenriched hemi-acyl azides and from there to either γ-amino acids or γ-lactams.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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