Research advances in palladium-catalysed intermolecular C–H annulation of aryl halides with various aromatic ring precursors

Organic & Biomolecular Chemistry Pub Date: 2022-07-12 DOI: 10.1039/D2OB01129H

Abstract

Transition-metal-catalysed C–H functionalization has emerged as a powerful approach for the transformation of organic molecules due to its high atom and step economy. Palladium-catalysed intermolecular C–H annulation of aryl halides, especially those involving annulation of a five-membered C,C-palladacycle with coupling reagents, have attracted considerable attention in the past decades. This review summarizes the progress on palladium-catalysed intermolecular C–H annulation of aryl halides with various aromatic ring precursors. Mechanistically, five-membered C,C-palladacycles as intermediates are involved in the majority of reactions.

Graphical abstract: Research advances in palladium-catalysed intermolecular C–H annulation of aryl halides with various aromatic ring precursors
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