Synthesis of 4-trifluoromethyl-2H-chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride?
Organic & Biomolecular Chemistry Pub Date: 2022-08-09 DOI: 10.1039/D2OB01177H
Abstract
Substituted on the benzene ring 4-CF3-2H-chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF3-2H-chromenes have been investigated. It has been shown that 4-CF3-2H-chromenes are convenient precursors to 4-CF3-coumarins.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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