Tuning the selectivity in iridium-catalyzed acceptorless dehydrogenative coupling of primary alcohols?
Organic & Biomolecular Chemistry Pub Date: 2022-07-29 DOI: 10.1039/D2OB01142E
Abstract
An acceptorless dehydrogenative coupling of primary alcohols to carboxylic acids/carboxylates, esters, and Guerbet alcohols (via both homo- and cross-β-alkylation of the alcohols) in the presence of an N-heterocyclic carbene iridium(I) catalyst was developed under aerobic conditions. The product selectivity can be easily tuned among the products with a single catalyst through simple modification of the reaction conditions, such as the catalyst and base amounts, the choice of base, and the reaction temperature.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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