Synthesis of 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of nitrile imines with ninhydrin-derived Morita–Baylis–Hillman carbonates?
Organic & Biomolecular Chemistry Pub Date: 2022-08-08 DOI: 10.1039/D2OB01253G
Abstract
An effective synthetic method for 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition reaction has been developed. This reaction could smoothly proceed between ninhydrin-derived Morita–Baylis–Hillman carbonates and nitrilimines to provide a wide scope of differently substituted pyrazoles in high yields (up to 95%). In addition, the reaction mechanism was also proposed to explain its regioselectivity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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