Efficient synthesis of spiro diheterocycles via multi-component dicyclization reaction?
Organic & Biomolecular Chemistry Pub Date: 2022-10-13 DOI: 10.1039/D2OB01368A
Abstract
A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2′-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two heterocycles and one valuable quaternary carbon in one pot via an in situ cyclization–respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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