N-Heterocyclic carbene-catalysed homoenolate addition reaction to 3-cyano-2-imino-2H-chromenes: synthesis of C4-functionalized 2-amino-3-cyano-4H-chromene?
Organic & Biomolecular Chemistry Pub Date: 2022-10-06 DOI: 10.1039/D2OB01447E
Abstract
A diastereoselective N-heterocyclic carbene-catalysed reaction between enal and 3-cyano-2-imino-2H-chromene is described for accessing a new type of C4-functionalized 2-amino-3-cyano-4H-chromene. A wide variety of enals and iminochromenes afforded the desired homoenolate addition product 2-amino-4H-chromenes in good yields and with moderate to good diastereoselectivities.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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