Iodine promoted cyclization of N,N′-diphenylthiocarbamides with enaminones: a protocol for the synthesis of poly-substituted 2-iminothiazolines?
Organic & Biomolecular Chemistry Pub Date: 2022-10-13 DOI: 10.1039/D2OB01477G
Abstract
An iodine promoted cyclization reaction between N,N′-diphenylthiocarbamides and enaminones was achieved, providing a series of poly-substituted 2-iminothiazolines. This protocol is transition metal free and simple to perform, with a broad functional group tolerance and good to excellent yields under mild reaction conditions, showing potential synthetic value for the preparation of a diversity of biologically and pharmaceutically active compounds.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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