Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines?
Organic & Biomolecular Chemistry Pub Date: 2022-11-02 DOI: 10.1039/D2OB01720B
Abstract
A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[b,d]oxepines is reported. This approach involves direct C–H and C–O bond activation followed by a ring annulation and features readily available starting materials, a broad substrate scope, good step economy and good scalability.
![Graphical abstract: Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines](http://scimg.chem960.com/usr/1/D2OB01720B.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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