Diyne-steered switchable regioselectivity in cobalt(ii)-catalysed C(sp2)–H activation of amides with unsymmetrical 1,3-diynes?
Organic & Biomolecular Chemistry Pub Date: 2023-02-08 DOI: 10.1039/D2OB02193E
Abstract
The regiochemical outcome of a cobalt(II) catalysed C–H activation reaction of aminoquinoline benzamides with unsymmetrical 1,3-diynes under relatively mild reaction conditions can be steered through the choice of diyne. The choice of diyne provides access to either 3- or 4-hydroxyalkyl isoquinolinones, paving the way for the synthesis of more highly elaborate isoquinolines.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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