I2-mediated coupling of quinazolinone enamines with 2-aminopyridines: a new strategy to access spiroquinazolinones?
Organic & Biomolecular Chemistry Pub Date: 2023-02-16 DOI: 10.1039/D3OB00083D
Abstract
Herein, we report a novel, rapid and efficient route to the spiroquinazolinone framework via an umpolung strategy mediated by molecular iodine. A library of functionalized spiroquinazolinone iodide salts was synthesized in moderate to good yields under ambient, metal-free and mild conditions. The current methodology opens up a new efficient and concise strategy for the construction of spiroquinazolinones.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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