Nickel-catalyzed reductive coupling of arylcarboxylic acid 2-pyridyl esters with alkyl methanesulfonates: access to alkyl aryl ketones?

Organic & Biomolecular Chemistry Pub Date: 2023-03-30 DOI: 10.1039/D3OB00293D

Abstract

Alkyl aryl ketones were synthesized via a nickel-catalyzed reductive coupling reaction of arylcarboxylic acid (2-pyridyl)esters with primary and secondary alkyl methanesulfonates under mild reaction conditions. This method suits a wide range of substrates and shows good compatibility with functional groups.

Graphical abstract: Nickel-catalyzed reductive coupling of arylcarboxylic acid 2-pyridyl esters with alkyl methanesulfonates: access to alkyl aryl ketones
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