Total synthesis of both enantiomers of the biosurfactant aureosurfactin via bidirectional synthesis with a chiral Horner–Wittig building block?

Organic & Biomolecular Chemistry Pub Date: 2023-05-24 DOI: 10.1039/D3OB00650F

Abstract

Aureosurfactin is a novel biosurfactant that exhibits similar surface tension activity to known biosurfactants. In this work, we now report a facile synthesis for aureosurfactin using a bidirectional synthetic strategy. Both enantiomers of the target compound were accessed from the (S)-building block, derived from the same chiral pool starting material.

Graphical abstract: Total synthesis of both enantiomers of the biosurfactant aureosurfactin via bidirectional synthesis with a chiral Horner–Wittig building block
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