RhIII-promoted directed C–H N-heteroarylation of 2-pyridones?
Organic & Biomolecular Chemistry Pub Date: 2023-05-30 DOI: 10.1039/D3OB00578J
Abstract
A catalytic protocol for the Cp*RhIII-promoted C6-selective N-heteroarylation of 2-pyridones with N-heterocyclic boronates has been successfully developed utilizing a removable pyridine auxiliary. This system features high efficiency with mild conditions and also tolerates ortho- and meta-substituted pyridines, pyrazoles, pyrimidine, non-substituted quinolines, thiophene and furan well. The easy synthetic approach could potentially be applied to construct heterocyclic drug molecules bearing 2-pyridone-heteroaryl motifs.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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