KOH-promoted cascade C–Cl bond activation and amidation of trichloromethyl aromatic compounds with formamides in water?
Organic & Biomolecular Chemistry Pub Date: 2023-06-08 DOI: 10.1039/D3OB00495C
Abstract
A KOH-promoted cascade C–Cl bond activation and amidation of trichloromethyl aromatic compounds with formamides using water as a solvent has been developed. This methodology suggested an alternative synthetic approach for the synthesis of aryl amide compounds in the absence of catalysts, additives and organic solvents. In addition, the yields of gram-scale reactions are good and provide a basis for synthetic application.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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