Design and development of intramolecular doubly vinylogous Michael addition to access 3-aryl substituted 2-alkenyl-benzofurans and -indoles?
Organic & Biomolecular Chemistry Pub Date: 2023-06-08 DOI: 10.1039/D3OB00861D
Abstract
Herein, we have disclosed a rare example of an intramolecular doubly vinylogous Michael addition (DVMA). The reaction design exploits the innate reactivity of ortho-heteroatom substituted para-quinone methide (p-QM) derivatives. The sequential reaction of p-QMs and activated allyl halides proceeds through heteroatom-allylation, DVMA and oxidation to furnish a diverse range of 2-alkenyl benzofuran and 2-alkenyl indole derivatives in high yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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