‘In-water’, nickel-catalyzed mild preparation of allylic amines employing alcohols: application to ‘a(chǎn)ll-water’ synthesis of pharmaceuticals?

Green Chemistry Pub Date: 2022-04-11 DOI: 10.1039/D2GC00308B

Abstract

Reported here is a nanomicelle-enabled, ‘in-water’, nickel-catalyzed allylic amination reaction using allylic alcohols under mild conditions (in the absence of additives/bases/activators). Different amines including electron-deficient N-heterocycles and allylic alcohols were found compatible with excellent selectivity (chemo/regio/stereo) and functional group tolerance. Additional features include scale-up synthesis, recycling, reuse of aqueous micelles (up to 5 runs), associated low E-factor, and low residual nickel in the product. Following the developed protocol, an “all-water” synthesis of flunarizine, cinnarizine, and naftifine was reported, wherein the step reactions are promoted by aqueous micelles, leading to a novel water-assisted total synthesis of marketed pharmaceuticals.

Graphical abstract: ‘In-water’, nickel-catalyzed mild preparation of allylic amines employing alcohols: application to ‘a(chǎn)ll-water’ synthesis of pharmaceuticals
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