Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries?
Green Chemistry Pub Date: 2022-05-23 DOI: 10.1039/D2GC00776B
Abstract
Aromatic and heteroaromatic ketones bearing an α-methine proton can be deprotonated and mono-allylated in minutes in the complete absence of an organic solvent to arrive at the corresponding products in high isolated yields. Applications to synthetic targets including both MK-7 and MK-9, as well as coenzyme Q9 (CoQ9), utilizing this new technology are documented.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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