Cyrene: a bio-based novel and sustainable solvent for organic synthesis

Green Chemistry Pub Date: 2022-07-28 DOI: 10.1039/D2GC02332F

Abstract

Dihydrolevoclucosenone (Cyrene is its market name) is a biomass-derived solvent that can be produced in only two steps from biomass, while being biodegradable, non-mutagenic and non-toxic. Its “green” profile combined with its physical properties makes Cyrene a plausible substitute for a number of widely used toxic organic solvents. The first attempt to assess Cyrene as a solvent dates back to 2014 and since then, numerous research groups have opted for this promising alternative. Cyrene has successfully been employed as a solvent in materials chemistry, peptide chemistry, organic synthesis and many more research fields, which are going to be discussed in the context of this review.

Graphical abstract: Cyrene: a bio-based novel and sustainable solvent for organic synthesis
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