Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source?

Green Chemistry Pub Date: 2023-03-22 DOI: 10.1039/D3GC00144J

Abstract

An environmentally benign electrochemical approach has been developed for the α-hydroxymethylation of ketones using N,N-dimethylformamide as the carbon source for the construction of β-hydroxy ketones. This method does not require metal catalysts or chemical oxidants and proceeded smoothly at room temperature to demonstrate tolerance of a broad range of functional groups.

Graphical abstract: Electrooxidative α-hydroxymethylation of ketones with dimethylformamide as the carbon source
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