Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles?
Green Chemistry Pub Date: 2023-05-02 DOI: 10.1039/D3GC00380A
Abstract
The electrochemical synthesis of 1H-indazoles via an intramolecular N(sp2)–H/N(sp3)–H coupling reaction at room temperature is first described. The transition metal-free electrochemical cyclization features the use of commercially available NH3 as the nitrogen source and a broad substrate scope, thus affording a wide range of substituted 1H-indazoles in moderate to good yields. Both the control experiments and mechanistic studies support the proposed reaction mechanism for this electrochemical cyclization.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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