Stoichiometric couplings of methylarenes through visible-light-induced bromo radical formation from aryl halides?
Green Chemistry Pub Date: 2022-03-18 DOI: 10.1039/D2GC00310D
Abstract
A visible-light/nickel dual catalyzed stoichiometric coupling of methylarenes via bromine radical-enhanced HAT has been developed. Aryl bromides serve as both cross-coupling partners and bromine radical precursors. Mechanistic studies reveal that the bromine radical acts as a highly efficient HAT reagent to abstract the benzylic C(sp3)–H bond to deliver a benzylic radical and subsequently engages in Ni-catalyzed arylation couplings. The synthetic utility of this approach is further proved by its application in the late-stage arylation or benzylation of several drug-like and complex molecules in a stoichiometric manner.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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