Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction?
Green Chemistry Pub Date: 2022-05-11 DOI: 10.1039/D2GC00724J
Abstract
We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea. The solvent-free procedure shows versatility and wide scope; it applies to a broad range of arylhydrazines and carbonyl compounds, leading to variously decorated indoles and indolenines. Upon suitable modification, the methodology can also allow preparing compounds of pharmaceutical interest.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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