Switchable electrooxidative N-methyl amines: access to C3-aminomethylated and C3-arylmethylated imidazo[1,2-a] pyridines?
Green Chemistry Pub Date: 2022-11-05 DOI: 10.1039/D2GC03464F
Abstract
Switchable approaches to accomplish the C3-aminomethylation and C3-arylmethylation of imidazo[1,2-a]pyridines with N-methylanilines using distinct electrochemical conditions have been developed. These two transformations exhibited notable regio- and chemoselectivities under air and metal/oxidant-free conditions. Remarkably, the environmentally benign electrochemical methods could be extended to the late-stage derivatization of natural products and drugs using N-methyl amines as a 1C source.
![Graphical abstract: Switchable electrooxidative N-methyl amines: access to C3-aminomethylated and C3-arylmethylated imidazo[1,2-a] pyridines](http://scimg.chem960.com/usr/1/D2GC03464F.jpg)
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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