Rose bengal photocatalyzed Knoevenagel condensation of aldehydes and ketones in aqueous medium?
Green Chemistry Pub Date: 2022-05-24 DOI: 10.1039/D2GC01402E
Abstract
Knoevenagel condensation is widely used in organic synthetic chemistry and several reaction conditions have been demonstrated. These reactions in neutral medium are challenging. In this report, we present a sustainable and greener method for Knoevenagel condensation reaction between carbonyl compounds (both aldehydes and ketones) and active methylene compounds using rose bengal as a photosensitizer in an aqueous medium. This protocol works smoothly for aromatic aldehydes and ketones containing both electron-donating and electron-withdrawing substituents.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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