From screening to the hectogram scale: sustainable electrochemical synthesis of mefenpyr-diethyl?
Green Chemistry Pub Date: 2023-08-01 DOI: 10.1039/D3GC02118A
Abstract
To demonstrate the technical application potential of electrochemical reactions, we developed a synthetic method to access the commercially available herbicide safener mefenpyr-diethyl. In a simple undivided electrolysis cell with non-hazardous aqueous sodium iodide as supporting electrolyte and mediator, the target compound was synthesized via the (E)- or (Z)-hydrazone. Environmentally benign solvents or solvent-free conditions ensure a sustainable process and excellent recycling of the excess reagents. Finally, scale-up to the hectogram scale was performed with good to excellent yield.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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