Ligand-free nickel catalyzed perfluoroalkylation of arenes and heteroarenes?
Chemical Science Pub Date: 2022-10-17 DOI: 10.1039/D2SC03879J
Abstract
We describe a “l(fā)igand-free” Ni-catalyzed perfluoroalkylation of heteroarenes to produce a diverse array of trfiluoromethyl, pentafluoroethyl and heptafluoropropyl adducts. Catalysis proceeds at room temperature via a radical pathway. The catalytic protocol is distinguished by its simplicity, and its wide scope demonstrates the potential in the late-stage functionalization of drug analogues and peptides.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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