Stereostructural analysis of flexible oxidized fatty acids by VCD spectroscopy?

Chemical Communications Pub Date: 2022-04-26 DOI: 10.1039/D2CC01337A

Abstract

Oxidation of polyunsaturated fatty acids produces various oxidized lipids whose absolute configuration (AC) and conformations are difficult to analyze due to their flexibility. Through studies on hydroxy fatty acids, lipid hydroperoxides, and lipid epoxides, this work demonstrates the effectiveness of VCD spectroscopy to elucidate their AC and conformational preferences.

Graphical abstract: Stereostructural analysis of flexible oxidized fatty acids by VCD spectroscopy
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