Palladium-catalyzed oxidative C–H activation/annulation of N-alkylanilines with bromoalkynes: access to functionalized 3-bromoindoles?
Chemical Communications Pub Date: 2022-08-02 DOI: 10.1039/D2CC03298H
Abstract
A straightforward approach to the synthesis of 3-bromoindoles via palladium-catalyzed oxidative C–H activation/annulation of N-alkylanilines with bromoalkynes has been described. This protocol features high atom economy, excellent chemo- and regioselectivities, and good functional group tolerance. Moreover, the resultant 3-bromoindoles can be transformed to various functionalized indole derivatives, which demonstrates the practicability of this method in organic synthesis.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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