Iron-catalyzed deconstructive alkylation through chlorine radical induced C–C single bond cleavage under visible light?
Chemical Communications Pub Date: 2022-08-12 DOI: 10.1039/D2CC03896J
Abstract
Selective C–C single bond cleavage of simple compounds is a highly challenging and desired process. Herein, a chlorine radical-induced deconstructive C–C bond alkylation with alcohols and alkenes catalyzed by iron salts was reported for the first time. Readily available alcohols and various electron-deficient alkenes were tolerated. Late-stage and large-scale reactions proceed smoothly. This catalyst system shows potential for diversified deconstructive functionalization of simple C–C bonds.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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