Copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes?

Chemical Communications Pub Date: 2022-05-17 DOI: 10.1039/D2CC00851C

Abstract

A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group compatibility and broad substrate scope.

Graphical abstract: Copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes
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