Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro?

Chemical Communications Pub Date: 2022-02-21 DOI: 10.1039/D2CC00372D

Abstract

A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

Graphical abstract: Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro
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