Carrier-free nanomedicine for enhanced photodynamic tumor therapy through glutathione S-transferase inhibition?
Chemical Communications Pub Date: 2022-02-24 DOI: 10.1039/D2CC00235C
Abstract
Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST) activity to hamper antioxidant systems and amplify intracellular oxidative stress for enhanced photodynamic therapy.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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