Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons?
Chemical Communications Pub Date: 2022-07-13 DOI: 10.1039/D2CC03856K
Abstract
We report the preparation of a new hydrocarbon-soluble magnesium amide TMP2Mg (TMP = 2,2,6,6-tetramethylpiperidyl). This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing ethyl esters and carbamates under very mild reaction conditions. Subsequent trapping with aryl iodides (Negishi cross-coupling) gave access to a range of highly functionalized valuable building blocks.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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