Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil?
Chemical Communications Pub Date: 2022-03-25 DOI: 10.1039/D1CC07187D
Abstract
Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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