Tandem synthesis of N-methylated tertiary amines via three-component coupling of carbonyl compounds, amines, and methanol?
Chemical Communications Pub Date: 2022-08-09 DOI: 10.1039/D2CC03115A
Abstract
An Ir-catalyzed tandem synthesis of various N-methylated tertiary amines from three-component coupling of carbonyl compounds, amines, and methanol following reductive amination/N-methylation is reported for the first time. A wide array of substrates with tolerance of different functional groups was demonstrated. The protocol was extended to the synthesis of N-methyl containing pharmaceutically important drug molecules. A probable catalytic cycle was proposed based on various control experiments and different analytical techniques such as NMR, IR and ESI-MS.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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