Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile?

Chemical Communications Pub Date: 2022-08-16 DOI: 10.1039/D2CC03081K

Abstract

Emerging synthetic development of chiral gold(III) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(III)Cl(R-DuPhos) (1–7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

Graphical abstract: Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile
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