Visible-light driven 3-hydroxybutyrate synthesis from CO2 and acetone with the hybrid system of photocatalytic NADH regeneration and multi-biocatalysts?

Chemical Communications Pub Date: 2022-09-07 DOI: 10.1039/D2CC03660F

Abstract

Poly-3-hydroxybutyrate (PHB)-derived plastics are polymer materials with excellent biodegradability, being insoluble in water and relatively resistant to hydrolysis. There is a need for a method capable of synthesizing 3-hydroxybutyrate, a monomer of PHB, from a renewable material. In this work, visible-light driven 3-hydroxybutyrate from CO2 and acetone with the system consisting of triethanolamine, water-soluble zinc porphyrin, pentamethylcyclopentadienyl coordinated rhodium complex, NAD+ and a cell extract containing acetone carboxylase and 3-hydroxybutyrate dehydrogenase from Rhodobacter capsulatus SB1003 cultured in acetone-bicarbonate medium is established. In particular, the conversion yield for acetone to 3-hydroxybutyrate was improved up to 81% in this system after 7 h irradiation.

Graphical abstract: Visible-light driven 3-hydroxybutyrate synthesis from CO2 and acetone with the hybrid system of photocatalytic NADH regeneration and multi-biocatalysts
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