Site-selective C–H alkylation of myo-inositol via organic photoredox catalysis?

Chemical Communications Pub Date: 2022-08-10 DOI: 10.1039/D2CC03569C

Abstract

Site-selective photoredox reactions with aromatic olefins enable direct alkylation of unprotected myo-inositol at C4. The efficacy of these reactions can be finely tuned by modifying the structures of HAT reagents. These reactions open the possibility of selective C–H alkylations of myo-inositol without the need for multi-step protection–deprotection strategies.

Graphical abstract: Site-selective C–H alkylation of myo-inositol via organic photoredox catalysis
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