Amide bond hydrolysis of peptoids?
Chemical Communications Pub Date: 2022-08-02 DOI: 10.1039/D2CC02717H
Abstract
Incorporating a chiral non-coordinating substitution at the N-terminal end within peptoids facilitates regio-selective amide bond hydrolysis mediated by a transition metal ion and/or an acidic buffer as evident by X-ray crystallographic analysis, supported by ESI-MS. This opens up a new direction for peptidomimetic compounds towards future application in chemistry, biology and medicine.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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