Development of the first non-hydroxamate selective HDAC6 degraders?
Chemical Communications Pub Date: 2022-09-01 DOI: 10.1039/D2CC03712B
Abstract
The targeted degradation of histone deacetylase 6 (HDAC6) by heterobifunctional degraders constitutes a promising approach to treat HDAC6-driven diseases. Previous HDAC6 selective degraders utilised a hydroxamic acid as a zinc-binding group (ZBG) which features mutagenic and genotoxic potential. Here we report the development of a new class of selective HDAC6 degraders based on a difluoromethyl-1,3,4-oxadiazole warhead as ZBG.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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