Asymmetric addition of an N-methyl C(sp3)–H bond to cyclic alkenes enabled by an iridium/phosphine–olefin catalyst?
Chemical Communications Pub Date: 2022-09-22 DOI: 10.1039/D2CC04642C
Abstract
Iridium-catalyzed asymmetric C–H addition of an N-methyl group on 3-trifluoromethyl-2-(N-methylamino)pyridine to cyclic alkenes was realized by using a phosphine–olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give the corresponding products in good yields with high enantioselectivity.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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