One-pot synthesis of 3-trifluoromethylbenzo[b][1,4]oxazines from CF3-imidoyl sulfoxonium ylides with 2-bromophenols?
Chemical Communications Pub Date: 2022-10-17 DOI: 10.1039/D2CC04863A
Abstract
Herein, a method to access 3-trifluoromethyl-1,4-benzoxazines from CF3-imidoyl sulfoxonium ylides and 2-bromophenols has been demonstrated. This synthetic protocol proceeds via a one-pot two-step sequence that includes the lithium-bromide-promoted O–H insertion of sulfoxonium ylides and annulation, and has the merits of broad substrate scope, excellent functional tolerance and operational simplicity, which provides an alternative means of obtaining CF3-substituted heterocycles.
![Graphical abstract: One-pot synthesis of 3-trifluoromethylbenzo[b][1,4]oxazines from CF3-imidoyl sulfoxonium ylides with 2-bromophenols](http://scimg.chem960.com/usr/1/D2CC04863A.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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