Concise total synthesis and structure revision of metacridamides A and B?

Chemical Communications Pub Date: 2023-07-26 DOI: 10.1039/D3CC01694C

Abstract

Concise total synthesis of metacridamides A and B was accomplished through repetitive vinylogous Mukaiyama aldol reactions and ynamide-mediated macrolactonization. Spectral data of both synthetic products were identical to those of the natural products, resulting in the revision of the absolute configuration of the C-9 position to be S.

Graphical abstract: Concise total synthesis and structure revision of metacridamides A and B
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