Asymmetric syn-selective direct aldol reaction of protected hydroxyacetone catalyzed by primary amino acid derived bifunctional organocatalyst in the presence of water?
Organic & Biomolecular Chemistry Pub Date: 2011-01-11 DOI: 10.1039/C0OB00898B
Abstract
A new series of water compatible primary-tertiary diamine catalysts derived from natural primary amino acids bearing a hydrophobic side chain have been synthesized. These new primary-tertiary diamine-Br?nsted acid conjugates bifunctional organocatalysts efficiently catalyzes the asymmetric direct syn selective cross-aldol reaction of different protected hydroxyacetone with various aldehydes in high yield (94%) and high enantioselectivity (up to 97% ee of syn) and dr of 91?:?9 (syn/anti) under mild reaction conditions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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