Palladium-catalyzed remote meta-C–H olefination of cinnamates??
Chemical Communications Pub Date: 2023-04-03 DOI: 10.1039/D3CC00289F
Abstract
The palladium-catalyzed remote meta-C–H olefination of geometrically challenging substituted cinnamates using a nitrile directing group derived from 2-cyanobenzoic acid has been described. This new protocol is applicable to various olefin coupling partners and provides the corresponding meta-olefinated products in very good yields and with high selectivity. In addition, using this methodology, a variety of acrylates with tethered bioactive molecules, such as naphthoquinone, methyl salicylate, paracetamol, thymol, sesamol, chalcone, naproxen, cholesterol and estrone, have been coupled to produce the desired meta-olefinated products.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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