Asymmetric Michael addition of α-fluoro-α-nitro esters to nitroolefins: towards synthesis of α-fluoro-α-substituted amino acids?
Organic & Biomolecular Chemistry Pub Date: 2015-01-07 DOI: 10.1039/C4OB02486A
Abstract
α-Fluoro-α-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, α-fluoro-α-amino ester with a quaternary α-carbon was prepared for the first time.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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