Asymmetric hydrogenation of O-/N-functional group substituted arenes

Chemical Communications Pub Date: 2021-10-19 DOI: 10.1039/D1CC04722A

Abstract

Asymmetric hydrogenation of aromatic compounds represents one of the most straightforward synthetic methods to construct important chiral cyclic skeletons that are often found in biologically active agents and natural products. So far, the most successful examples in this field are largely limited to aromatics containing alkyl and aryl substituted groups due to the poor functional-group tolerance of hydrogenation. Direct asymmetric hydrogenation of functionalized aromatics provides enormous potential for expanding the structural diversity of reductive products of planar aromatic compounds, which is highly desirable and has not been well studied. This feature article focuses on the progress in catalytic asymmetric hydrogenation and transfer hydrogenation of O/N substituted arenes.

Graphical abstract: Asymmetric hydrogenation of O-/N-functional group substituted arenes
Recommended Literature