Facile preparation of N-tert-butyl amides under heat-, metal- and acid-free conditions by using tert-butyl nitrite (TBN) as a practical carbon source?

Chemical Communications Pub Date: 2023-04-25 DOI: 10.1039/D3CC01168B

Abstract

tert-Butyl nitrite (TBN) is a nontoxic substance that has frequently been used as a source of nitrogen, oxygen, or nitric oxide (NO), but not as a carbon source in chemical transformations. Here, for the first time to the best of our knowledge, we introduced TBN as a source of carbon (tert-butyl group) for the synthesis of highly valuable N-tert-butyl amides from nitriles and water under very mild conditions.

Graphical abstract: Facile preparation of N-tert-butyl amides under heat-, metal- and acid-free conditions by using tert-butyl nitrite (TBN) as a practical carbon source
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